Chaen T, Watanabe N, Mogi G, Mori K, Takeyama M
Dept. of Otolaryngology, Oita Medical University, Japan.
Ann Otol Rhinol Laryngol. 1993 Jan;102(1 Pt 1):16-21. doi: 10.1177/000348949310200104.
To clarify the role of substance P (SP) and vasoactive intestinal peptide (VIP) in nasal allergy, we measured their concentrations in the nasal secretions and plasma of normal subjects and patients with nasal allergy to house dust and Japanese cedar pollen by competitive enzyme-linked immunoassay. The mean levels of SP (224 pmol/L) and VIP (41.6 pmol/L) in the nasal secretions of normal subjects were significantly higher than those in plasma (SP 3.04 pmol/L and VIP 1.04 pmol/L; p < .01). The mean levels of SP and VIP in the nasal secretions of the pollinosis group were significantly higher than those of the control group (p < .05 and p < .01), while the levels of the house dust allergy group were not higher than those of the control group. Intranasal allergen challenge significantly reduced SP levels in the nasal secretions of the allergy groups, while it did not influence VIP levels in the nasal secretions. These findings suggest that SP and VIP are actively secreted into the nose and may play an important role in the allergic reaction on the surface of the human nasal mucosa.
为阐明P物质（SP）和血管活性肠肽（VIP）在鼻过敏中的作用，我们采用竞争性酶联免疫分析法，检测了正常受试者以及对屋尘和日本雪松花粉过敏的鼻过敏患者鼻分泌物和血浆中它们的浓度。正常受试者鼻分泌物中SP的平均水平（224 pmol/L）和VIP的平均水平（41.6 pmol/L）显著高于血浆中的水平（SP为3.04 pmol/L，VIP为1.04 pmol/L；p < 0.01）。花粉症组鼻分泌物中SP和VIP的平均水平显著高于对照组（p < 0.05和p < 0.01），而屋尘过敏组的水平不高于对照组。鼻内过敏原激发显著降低了过敏组鼻分泌物中的SP水平，而对鼻分泌物中的VIP水平没有影响。这些发现表明，SP和VIP被主动分泌到鼻腔中，可能在人类鼻黏膜表面的过敏反应中起重要作用。
