Shahsuvaryan M L, Melkonyan A K
Ophthalmologic Centre, Yerevan, Armenia.
Eur J Ophthalmol. 2003 Jun;13(5):445-52. doi: 10.1177/112067210301300505.
To identify risk factors for central retinal vein occlusion (CRVO).
This clinic-based case-control study included 408 patients with CRVO aged 21 years and older and 566 controls who were seen between January 1, 1990, and December 31, 2001. Multivariate logistic regression analysis was used to adjust for various factors and test potential interactions between the different variables.
An increased risk of CRVO was found in persons with systemic hypertension, but odds ratios were greater for older patients. Risk of CRVO increases with age and also in association with hypercoagulability. Diabetes mellitus, kidney disease, and glaucoma were associated with increased risk for CRVO. A significantly greater prevalence of higher erythrocyte sedimentation rate was present in young adults compared with older patients.
The results suggest a relationship between CRVO and certain risk factors (systemic hypertension, diabetes mellitus, kidney disease, glaucoma, older age) and support the possibility of an association between CRVO and urban location. The findings also support the potential value of medical treatment of underlying medical conditions in preventing occurrence of CRVO.
确定视网膜中央静脉阻塞（CRVO）的危险因素。
这项基于诊所的病例对照研究纳入了408例年龄在21岁及以上的CRVO患者和566例对照，这些患者和对照于1990年1月1日至2001年12月31日期间就诊。采用多因素逻辑回归分析来校正各种因素，并检验不同变量之间的潜在相互作用。
发现系统性高血压患者发生CRVO的风险增加，但老年患者的优势比更高。CRVO的风险随年龄增加而增加，并且与高凝状态有关。糖尿病、肾脏疾病和青光眼与CRVO风险增加相关。与老年患者相比，年轻成年人中红细胞沉降率较高的患病率显著更高。
结果表明CRVO与某些危险因素（系统性高血压、糖尿病、肾脏疾病、青光眼、老年）之间存在关联，并支持CRVO与城市居住地点之间存在关联的可能性。这些发现还支持对潜在疾病进行医学治疗在预防CRVO发生方面的潜在价值。
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