Ørskov Marie, Vorum Henrik, Larsen Torben Bjerregaard, Lip Gregory Y H, Bek Toke, Skjøth Flemming
Department of Cardiology, Aalborg University Hospital, Hobrovej 18-22, 9000, Aalborg, Denmark.
Aalborg Thrombosis Research Unit, Department of Clinical Medicine, Faculty of Health, Aalborg University, Aalborg, Denmark.
Int Ophthalmol. 2023 Mar;43(3):817-824. doi: 10.1007/s10792-022-02483-3. Epub 2022 Sep 2.
To investigate the relationship between risk factors for retinal artery occlusion (RAO) and retinal vein occlusion (RVO) and thereby identify similarities and differences between the two types of retinal vascular occlusions.
In this case-control study, 5708 patients with RAO were included and matched with three patients with RVO each. The patients with RVO were matched on sex and age at index date. All patients, personal information, diagnoses, and prescriptions were obtained from the Danish nationwide registries. Adjusted conditional logistic regression was used to investigate the association of RAO and RVO with the included risk factors.
RAO was stronger associated with arterial hypertension, heart failure, ischemic heart disease, peripheral artery disease, and stroke than RVO, with effect measures ranging from 1.10 to 2.21. RVO was associated with cataract and glaucoma with effect measures of 0.80 (95% CI 0.73-0.87) and 0.65 (95% CI 0.56-0.76), respectively.
Differences in the level of associations with the included risk factors suggests differences in the pathophysiologies of the two diseases. The main pathophysiology associated with RAO was atherosclerosis, whereas the main pathophysiology associated with RVO was changes in the pressure gradients of the eyes.
研究视网膜动脉阻塞（RAO）和视网膜静脉阻塞（RVO）的危险因素之间的关系，从而确定这两种视网膜血管阻塞类型之间的异同。
在这项病例对照研究中，纳入了5708例RAO患者，并为每位患者匹配3例RVO患者。RVO患者在索引日期的性别和年龄上进行匹配。所有患者的个人信息、诊断和处方均来自丹麦全国性登记处。采用调整后的条件逻辑回归分析来研究RAO和RVO与纳入的危险因素之间的关联。
与RVO相比，RAO与动脉高血压、心力衰竭、缺血性心脏病、外周动脉疾病和中风的相关性更强，效应量范围为1.10至2.21。RVO与白内障和青光眼相关，效应量分别为0.80（95%CI 0.73-0.87）和0.65（95%CI 0.56-0.76）。
与纳入的危险因素的关联程度差异表明这两种疾病的病理生理学存在差异。与RAO相关的主要病理生理学是动脉粥样硬化，而与RVO相关的主要病理生理学是眼内压力梯度的变化。
