Chen Tony Y, Uppuluri Aditya, Zarbin Marco A, Bhagat Neelakshi
The Institute of Ophthalmology and Visual Science, Rutgers-New Jersey Medical School, Newark, NJ, USA.
Eur J Ophthalmol. 2021 Sep;31(5):2546-2555. doi: 10.1177/1120672120960333. Epub 2020 Oct 2.
Several risk factors have been identified for central retinal vein occlusion (CRVO) in older population. CRVO in young is uncommon, and the risk factors for this group are unclear. This large retrospective, cross-sectional study used the National Inpatient Sample (NIS) database to evaluate the risk factors for CRVO in patients 18 to 40 years of age.
The 2002 to 2014 NIS database was used. All patients 18 to 40 years of age with a primary diagnosis of CRVO were identified. Age- and gender-matched non-CRVO controls were randomly selected. The primary outcome was identification of risk factors for CRVO. Chi-square analysis and Firth logistic regression were performed with IBM SPSS 23 and R packages versions 3.4.3, respectively. < 0.05 was considered significant.
A total of 95 weighted young CRVO patients were identified. The average age was 31.44 ± 6.41 years with no gender predilection. Systemic and ocular conditions found to have statistically significant associations with CRVO included primary open-angle glaucoma (POAG) (OR 836.72, < 0.001), retinal vasculitis (OR 705.82, < 0.001), pseudotumor cerebri (OR 35.94, < 0.001), hypercoagulable state (OR 25.25, < 0.001), history of deep vein thrombosis/pulmonary embolism (DVT/PE) (OR 21.88, < 0.001), and hyperlipidemia (OR 3.60, = 0.003).
The most significant risk factors for CRVO in young adults were POAG, retinal vasculitis, and pseudotumor cerebri. Hypercoagulable states and DVT/PE were also associated with CRVO in this population. Systemic inflammatory conditions were not associated with CRVO. Traditional risk factors such as hypertension and diabetes did not pose significant risks, whereas hyperlipidemia was deemed a significant risk factor.
已确定老年人群中心视网膜静脉阻塞（CRVO）的几种危险因素。年轻人患CRVO并不常见，且该群体的危险因素尚不清楚。这项大型回顾性横断面研究使用国家住院样本（NIS）数据库评估18至40岁患者CRVO的危险因素。
使用2002年至2014年的NIS数据库。确定所有18至40岁原发性诊断为CRVO的患者。随机选择年龄和性别匹配的非CRVO对照。主要结果是确定CRVO的危险因素。分别使用IBM SPSS 23和R软件包版本3.4.3进行卡方分析和Firth逻辑回归。P < 0.05被认为具有统计学意义。
共确定了95例加权的年轻CRVO患者。平均年龄为31.44 ± 6.41岁，无性别倾向。发现与CRVO有统计学显著关联的全身和眼部疾病包括原发性开角型青光眼（POAG）（比值比836.72，P < 0.001）、视网膜血管炎（比值比705.82，P < 0.001）、假性脑瘤（比值比35.94，P < 0.001）、高凝状态（比值比25.25，P < 0.001）、深静脉血栓形成/肺栓塞（DVT/PE）病史（比值比21.88，P < 0.001）和高脂血症（比值比3.60，P = 0.003）。
年轻成年人中CRVO最显著的危险因素是POAG、视网膜血管炎和假性脑瘤。高凝状态和DVT/PE在该人群中也与CRVO相关。全身性炎症性疾病与CRVO无关。高血压和糖尿病等传统危险因素没有构成显著风险，而高脂血症被认为是一个显著的危险因素。
