Taysi K
Clin Genet. 1975 Nov;8(5):319-23. doi: 10.1111/j.1399-0004.1975.tb01509.x.
Association patterns of acrocentric chromosomes in 3032 cells from chromosomally normal parents of regular mongols (nondisjunctional trisomy 21) and normal controls were studied by the Giemsa banding technique. In each group, chromosome No. 21 was found to be involved in satellite association more frequently than other acrocentric chromosomes. The most frequently seen association was between No. 21 and 22. However, no difference was shown between the parental test group and the normal controls in regard to these frequencies. These results render less tenable the proposed linkage between satellite association and the etiology of mongolism.
运用吉姆萨显带技术，对3032例来自典型先天愚型（21号染色体不分离三体）染色体正常的父母及正常对照者的细胞中的近端着丝粒染色体的联合模式进行了研究。在每组中，发现21号染色体比其他近端着丝粒染色体更频繁地参与随体联合。最常见的联合发生在21号和22号染色体之间。然而，就这些频率而言，亲代试验组与正常对照组之间未显示出差异。这些结果使得关于随体联合与先天愚型病因学之间所提出的联系变得不太可信。
