Hungerford D A, Mellman W J, Balaban G B, LaBadie G U, Messatzzia L R, Haller G
Proc Natl Acad Sci U S A. 1970 Sep;67(1):221-4. doi: 10.1073/pnas.67.1.221.
Recently developed pachytene maps of the two small acrocentric autosomes (numbers 21 and 22) of man have been applied to a case of Down's syndrome mosaic for normal and trisomic cells (46,XY/47,XY,21+). Trivalents in trisomic spermatocytes, and thus the supernumerary chromosome, were recognized as compatible in length and chromomere pattern with the shorter of these two chromosomes at the pachytene stage. With the exception of the region of the centromere and the short arm, association among constituents of the trivalent appeared complete.
最近绘制的人类两条小近端着丝粒常染色体（21号和22号）的粗线期图谱，已应用于一例具有正常细胞和三体细胞（46,XY/47,XY,21 +）的唐氏综合征嵌合体病例。三体精母细胞中的三价体，以及额外的染色体，在粗线期被认为在长度和染色粒模式上与这两条染色体中较短的那条相匹配。除了着丝粒区域和短臂外，三价体各组成部分之间的联会似乎是完全的。
