McNair A N, Kerr I M
Imperial Cancer Research Fund, London, U.K.
Pharmacol Ther. 1992;56(1):79-95. doi: 10.1016/0163-7258(92)90038-2.
In response to interferon (IFN), cells develop an antiviral state in which the replication of a wide spectrum of RNA and DNA viruses is inhibited. Viruses have evolved a variety of mechanisms to inhibit the production and action of the interferons. Interferon action may be blocked by inhibition of the post-receptor signalling pathway, which prevents the expression of a number of proteins with antiviral properties. Other viruses prevent the action of specific, interferon-induced antiviral systems. In particular, the action of the dsRNA-dependent protein kinase (DAI) is inhibited by a variety of different viruses, indicating the fundamental importance of this enzyme to the antiviral response.
作为对干扰素（IFN）的反应，细胞会形成一种抗病毒状态，在此状态下多种RNA和DNA病毒的复制受到抑制。病毒已经进化出多种机制来抑制干扰素的产生和作用。干扰素的作用可能会因受体后信号通路的抑制而受阻，这会阻止许多具有抗病毒特性的蛋白质的表达。其他病毒则会阻止特定的、干扰素诱导的抗病毒系统发挥作用。特别是，多种不同病毒会抑制双链RNA依赖性蛋白激酶（DAI）的作用，这表明该酶对抗病毒反应至关重要。
