人类导航中依赖海马体和尾状核的认知策略：变异性及随练习的变化
Cognitive strategies dependent on the hippocampus and caudate nucleus in human navigation: variability and change with practice.
作者信息
Iaria Giuseppe, Petrides Michael, Dagher Alain, Pike Bruce, Bohbot Véronique D
机构信息
Douglas Hospital Research Center, McGill University, Verdun, Quebec, Canada, H4H 1R3.
出版信息
J Neurosci. 2003 Jul 2;23(13):5945-52. doi: 10.1523/JNEUROSCI.23-13-05945.2003.
Abstract
The human brain activity related to strategies for navigating in space and how it changes with practice was investigated with functional magnetic resonance imaging. Subjects used two different strategies to solve a place-learning task in a computer-generated virtual environment. One-half of the subjects used spatial landmarks to navigate in the early phase of training, and these subjects showed increased activation of the right hippocampus. The other half used a nonspatial strategy and showed, with practice, sustained increased activity within the caudate nucleus during navigation. Activation common to both groups was observed in the posterior parietal and frontal cortex. These results provide the first evidence for spontaneous variability and shift in neural mechanisms during navigation in humans.
摘要
通过功能磁共振成像研究了与空间导航策略相关的人类大脑活动及其如何随练习而变化。受试者在计算机生成的虚拟环境中使用两种不同策略来解决位置学习任务。一半受试者在训练早期使用空间地标进行导航，这些受试者右侧海马体激活增加。另一半使用非空间策略，并且随着练习，在导航过程中尾状核内的活动持续增加。两组共同的激活出现在顶叶后部和额叶皮质。这些结果为人类导航过程中神经机制的自发变异性和转变提供了首个证据。
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