Liu Bin, Dong Xiao Li, Xie Jun Xia, Gou Yu Lin, Rowlands Dewi Kenneth, Chan Hsiao Chang
Department of Physiology, College of Medicine, Qingdao University, PR China.
Biol Pharm Bull. 2003 Jul;26(7):1028-30. doi: 10.1248/bpb.26.1028.
To investigate whether Bak Foong Pills (BFP), a well-known gynaecological tonic, has a direct effect on the central nervous system, we employed the in vivo electrochemical detection technique, fast cyclic voltammetry (FCV), to measure the dopamine release from the mesolimbic structure-amygdala of both male and female rats. The results showed that intracerebroventricular BFP (0.75, 1.5 microg) treatment promoted dopamine release from the amygdala in both female and ovariectomized female rats. The BFP-induced response appeared within 5 min after addition of BFP and lasted for at least 40 min. However, no effect of BFP was observed in male rats for an observed period of up to 60 min. The results suggest that BFP may have gender-specific beneficial effect on dopaminergic functions of the amygdala.
为研究知名妇科滋补品白凤丸（BFP）是否对中枢神经系统有直接作用，我们采用体内电化学检测技术——快速循环伏安法（FCV），来测量雄性和雌性大鼠中脑边缘结构——杏仁核的多巴胺释放量。结果显示，脑室内注射BFP（0.75、1.5微克）可促进雌性大鼠及去卵巢雌性大鼠杏仁核释放多巴胺。添加BFP后5分钟内出现BFP诱导的反应，并持续至少40分钟。然而，在长达60分钟的观察期内，未观察到BFP对雄性大鼠有任何作用。结果表明，BFP可能对杏仁核的多巴胺能功能具有性别特异性的有益作用。
