Deliveliotis C, Skolarikos A, Karayannis A, Tzelepis V, Trakas N, Alargof E, Protogerou V
University of Athens, Sismanoglio Hospital, Athens. Greece.
World J Urol. 2003 Aug;21(3):171-6. doi: 10.1007/s00345-003-0345-0. Epub 2003 Jul 3.
This study assesses the correlation of p53 immunoreactivity and DNA ploidy status with biochemical recurrence after radical prostatectomy. p53 protein expression and DNA ploidy were evaluated on 84 archival paraffin-embedded radical prostatectomy specimens. Patients were divided into two groups: those with low (38/84, 45%) and those with high (46/84, 55%) p53 immunoreactivity. The results were correlated with Gleason score, stage and serum PSA. Kaplan-Meier biochemical recurrence free survival and the Cox hazard-regression model were used for analysis. Multivariate analysis revealed p53, DNA ploidy, Gleason score, PSA and stage to be independent prognostic factors in this order. Kaplan-Meier analysis showed a significant difference in biochemical recurrence when p53 high expression and DNA aneuploidy were combined. The results of this study suggest that stratification for p53 expression and DNA ploidy status can provide additional prognostic information for patients with prostate carcinoma after radical prostatectomy.
本研究评估了p53免疫反应性和DNA倍体状态与根治性前列腺切除术后生化复发的相关性。对84份存档石蜡包埋的根治性前列腺切除标本进行了p53蛋白表达和DNA倍体评估。患者分为两组：p53免疫反应性低的患者（38/84，45%）和p53免疫反应性高的患者（46/84，55%）。结果与Gleason评分、分期和血清PSA相关。采用Kaplan-Meier无生化复发生存率和Cox风险回归模型进行分析。多因素分析显示，p53、DNA倍体、Gleason评分、PSA和分期依次为独立的预后因素。Kaplan-Meier分析显示，当p53高表达与DNA非整倍体同时存在时，生化复发存在显著差异。本研究结果表明，对p53表达和DNA倍体状态进行分层可为根治性前列腺切除术后的前列腺癌患者提供额外的预后信息。
