Woods Mark, Sherry A Dean
Department of Chemistry, University of Texas at Dallas, Richardson, Texas 75083, and Rogers Magnetic Resonance Center, Department of Radiology, University of Texas Southwestern Medical Center, 5801 Forest Park Road, Dallas, Texas 75235, USA.
Inorg Chem. 2003 Jul 14;42(14):4401-8. doi: 10.1021/ic0300823.
DOTA-tetraamide ligands having extended phenol or pyridine substituents have been synthesized. The (5)D(0) --> (7)F(J) deltaJ = 1 and 2 emission bands in the corresponding europium(III) complexes differ in their sensitivity to solution pH. This offers the potential for developing pH responsive probes for in vivo imaging that are independent of probe concentration.
已合成具有延伸酚基或吡啶取代基的DOTA-四酰胺配体。相应铕(III)配合物中的(5)D(0)→(7)F(J)δJ = 1和2发射带对溶液pH的敏感性不同。这为开发独立于探针浓度的用于体内成像的pH响应探针提供了潜力。