一种功能化高亲和力甘露糖受体配体的合成及其在肽、聚酰胺和肽核酸缀合物构建中的应用。
Synthesis of a functionalized high affinity mannose receptor ligand and its application in the construction of peptide-, polyamide- and PNA-conjugates.
作者信息
Kinzel Olaf, Fattori Daniela, Ingallinella Paolo, Bianchi Elisabetta, Pessi Antonello
机构信息
Department of Molecular and Cell Biology, IRBM P. Angeletti, Via Pontina Km 30.600, 00040 Pomezia (Rome), Italy.
出版信息
J Pept Sci. 2003 Jun;9(6):375-85. doi: 10.1002/psc.463.
DOI:10.1002/psc.463
PMID:12846483
Abstract
The synthesis of a high affinity mannose receptor ligand, appropriately functionalized for chemoselective ligation with an antigen or DNA-binding moieties is described. By a combination of solid- and solution-phase chemistry a versatile synthesis of the target structure was accomplished. Examples of subsequent ligation reactions are described.
摘要
本文描述了一种高亲和力甘露糖受体配体的合成方法，该配体经过适当功能化处理，可与抗原或DNA结合部分进行化学选择性连接。通过固相化学和溶液相化学相结合的方法，实现了目标结构的通用合成。文中还描述了后续连接反应的实例。
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