Bagan Jose V, Jimenez Yolanda, Sanchis Jose M, Poveda Rafael, Milian Mari A, Murillo Judith, Scully Crispian
Department of Stomatology, Oral Medicine, University General Hospital, Valencia University, Valencia, Spain.
J Oral Pathol Med. 2003 Aug;32(7):379-82. doi: 10.1034/j.1600-0714.2003.00167.x.
Proliferative verrucous leukoplakia (PVL) is a multifocal and progressive lesion of the oral mucosa, often associated with papillomavirus, seen mainly in older females, and characterized by a high recurrence rate and high rate of transformation into verrucous or oral squamous cell carcinoma (OSCC). The aim of this study was to analyse the clinical characteristics of a substantial group of patients with PVL, evaluating the characteristics of those who developed cancer, and comparing them with a group of patients with OSCC but no preceding PVL.
A group of 30 patients with PVL was studied for the clinical aspects and characteristics, age, sex, location, recurrence, the appearance of new lesions, and the frequency of development of oral cancer. A disease control group was formed with 110 patients with OSCC chosen randomly from among those treated in the same Service in this period of time. The patients were grouped as PVL and no cancer (Group 1); PVL developing cancer (Group 2) and patients with OSCC without clinical lesions associated with PVL (Group 3).
The average age of the PVL patients (Groups 1 and 2 combined) was 70.97 +/- 12.73 years, of which 80% were women. Only 23.3% were cigarette smokers. The area most frequently affected with PVL was the lower gingiva. Recurrence after treatment was seen in 86.7%, and new lesions appeared in 83.3%. Many (63.3%) developed cancer (Group 2). Comparison of Groups 2 and 3 patients showed that those with PVL developing cancer were more likely to develop gingival carcinoma and also to be older, more often females, and less likely to smoke tobacco.
Cancer developing in patients with PVL manifested particularly on the gingiva.
增殖性疣状白斑（PVL）是一种口腔黏膜的多灶性进行性病变，常与乳头瘤病毒相关，主要见于老年女性，其特点是复发率高且转化为疣状癌或口腔鳞状细胞癌（OSCC）的几率高。本研究的目的是分析大量PVL患者的临床特征，评估发生癌变患者的特征，并将其与一组无PVL病史的OSCC患者进行比较。
对30例PVL患者的临床情况、特征、年龄、性别、病变部位、复发情况、新病变出现情况以及口腔癌发生频率进行研究。设立疾病对照组，从同期在同一科室接受治疗的患者中随机选取110例OSCC患者。患者分为PVL未发生癌变组（第1组）；PVL发生癌变组（第2组）；以及无PVL相关临床病变的OSCC患者组（第3组）。
PVL患者（第1组和第2组合并）的平均年龄为70.97±12.73岁，其中80%为女性。仅有23.3%为吸烟者。PVL最常累及的部位是下牙龈。治疗后复发率为86.7%，出现新病变的比例为83.3%。许多患者（63.3%）发生了癌变（第2组）。第2组和第3组患者比较显示，PVL发生癌变的患者更易发生牙龈癌，年龄更大，女性更常见，吸烟可能性更小。
PVL患者发生的癌变尤其表现在牙龈。
