Heim M U, Munker R, Sauer H, Wolf-Hornung B, Knabe H, Holler E, Böck M, Mempel W
Transfusionszentrum/Medizinische Klinik III im Klinikum Grosshadern, Ludwig-Maximilians-Universität München, BRD.
Beitr Infusionsther. 1992;30:178-81.
Transfusion-associated graft-versus-host disease (TA-GVHD) resulting from the engraftment of competent lymphocytes contained in blood products has been well described in immunocompromised patients and more recently in immunocompetent patients. Prophylactic irradiation of blood products prior to transfusion is the most efficient way to prevent TA-GVHD. Standard blood bank measures to reduce mononuclear cell contamination in red blood cell units, such as freezing, washing and filtration, may reduce the number of viable lymphocytes to prevent immunizations. However, it is unknown whether the depletion of leukocytes with these techniques would decrease the risk of TA-GVHD. In this report we describe the first case of TA-GVHD following transfusion of filtrated red blood cells given to a patient receiving cytotoxic therapy for Hodgkin's disease.
输血相关移植物抗宿主病（TA-GVHD）是由血液制品中存在的有功能的淋巴细胞植入引起的，在免疫功能低下的患者中已有详细描述，最近在免疫功能正常的患者中也有报道。输血前对血液制品进行预防性照射是预防TA-GVHD的最有效方法。血库为减少红细胞单位中单核细胞污染所采取的标准措施，如冷冻、洗涤和过滤，可能会减少存活淋巴细胞的数量以预防免疫反应。然而，尚不清楚采用这些技术去除白细胞是否会降低TA-GVHD的风险。在本报告中，我们描述了首例TA-GVHD病例，该病例发生在一名接受霍奇金病细胞毒性治疗的患者输注过滤红细胞之后。
