Metselaar H, Weimar W
Department of Internal Medicine, University Hospital Rotterdam-Dijkzigt, The Netherlands.
Beitr Infusionsther. 1992;30:198-202.
We performed a meta-analysis of 6 randomized clinical trials to study the efficacy of passive immunization against CMV in solid organ transplantation. The results indicate that passive immunization against CMV prevents (fatal) CMV disease in CMV seronegative recipients of a CMV seropositive allograft, even when treated with additional immunosuppression in case of rejections. Passive immunization with anti-CMV immunoglobulin preparations did not reduce the incidence of CMV infection or disease in CMV seropositive recipients.
我们对6项随机临床试验进行了荟萃分析，以研究实体器官移植中被动免疫预防巨细胞病毒（CMV）感染的疗效。结果表明，对于接受CMV血清反应阳性同种异体移植物的CMV血清反应阴性受者，被动免疫可预防（致命的）CMV疾病，即使在发生排斥反应时接受额外免疫抑制治疗的情况下也是如此。使用抗CMV免疫球蛋白制剂进行被动免疫并未降低CMV血清反应阳性受者中CMV感染或疾病的发生率。
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