Glosser G, Salvucci A E, Chiaravalloti N D
Department of Neurology, University of Pennsylvania, Philadelphia 19104-4283, USA.
Neurology. 2003 Jul 8;61(1):81-6. doi: 10.1212/01.wnl.0000073621.18013.e1.
To assess naming and recognition of faces of familiar famous people in patients with epilepsy before and after anterior temporal lobectomy (ATL).
Color photographs of famous people were presented for naming and description to 63 patients with temporal lobe epilepsy (TLE) either before or after ATL and to 10 healthy age- and education-matched controls.
Spontaneous naming of photographed famous people was impaired in all patient groups, but was most abnormal in patients who had undergone left ATL. When allowed to demonstrate knowledge of the famous faces through verbal descriptions, rather than naming, patients with left TLE, left ATL, and right TLE improved to normal levels, but patients with right ATL were still impaired, suggesting a new deficit in identifying famous faces. Naming of famous people was related to naming of other common objects, verbal memory, and perceptual discrimination of faces. Recognition of the identity of pictured famous people was more related to visuospatial perception and memory.
Lesions in anterior regions of the right temporal lobe impair recognition of the identities of familiar faces, as well as the learning of new faces. Lesions in the left temporal lobe, especially in anterior regions, disrupt access to the names of known people, but do not affect recognition of the identities of famous faces. Results are consistent with the hypothesized role of lateralized anterior temporal lobe structures in facial recognition and naming of unique entities.
评估前颞叶切除术（ATL）前后癫痫患者对熟悉名人面孔的命名和识别能力。
向63例颞叶癫痫（TLE）患者（ATL术前或术后）以及10名年龄和教育程度匹配的健康对照者展示名人彩色照片，要求他们进行命名和描述。
所有患者组对名人照片的自发命名能力均受损，但在接受左侧ATL的患者中最为异常。当允许通过语言描述而非命名来展示对名人面孔的了解时，左侧TLE、左侧ATL和右侧TLE患者的表现改善至正常水平，但右侧ATL患者仍有受损，这表明在识别名人面孔方面出现了新的缺陷。名人命名与其他常见物体的命名、言语记忆以及面孔的知觉辨别有关。对照片中名人身份的识别更多地与视觉空间感知和记忆有关。
右侧颞叶前部病变会损害对熟悉面孔身份的识别以及新面孔的学习。左侧颞叶病变，尤其是前部病变，会干扰对已知人物名字的提取，但不影响对名人面孔身份的识别。研究结果与外侧化前颞叶结构在面部识别和独特实体命名中的假设作用一致。
