Wimmer A, Graf A, Wank R
Institut für Immunologie, München, BRD.
Beitr Infusionsther. 1992;30:349-53.
HLA molecules serve as identity markers for immunocompetent cells which respond to pathogens and transplant tissue antigens to distinguish self from non-self. The continuous discovery of new HLA polymorphisms which are associated with various diseases or are involved in graft rejection continuously increases the number of HLA antigens which need to be identified for each individual. We defined the HLA class I and HLA class II antigens with the NIH standard microcytotoxicity system and compared the results with those obtained using the commercially available automated Patimed system. Our results show that serological identification of HLA antigens with the Patimed system is reliable. It can be recommended for routine as well as for research purposes.
HLA分子作为免疫活性细胞的身份标记，这些细胞对病原体和移植组织抗原作出反应，以区分自我与非自我。与各种疾病相关或参与移植排斥反应的新HLA多态性的不断发现，持续增加了每个个体需要鉴定的HLA抗原数量。我们使用美国国立卫生研究院标准微量细胞毒性系统定义了HLA I类和HLA II类抗原，并将结果与使用市售自动化Patimed系统获得的结果进行比较。我们的结果表明，使用Patimed系统对HLA抗原进行血清学鉴定是可靠的。它可推荐用于常规以及研究目的。
