Pacios María Gabriela, de la Casa María Luisa, de los Angeles Bulacio María, López María Elena
Cátedra de Química Biológica, Facultad de Odontología, Universidad Nacional de Tucumán, San Miguel de Tucumán, Argentina.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Jul;96(1):96-101. doi: 10.1016/s1079-2104(02)91705-1.
Calcium hydroxide, Ca(OH)(2), is a common intracanal medicament. Ca(OH)(2) powder can be mixed with different vehicles and used as a paste for temporary intracanal treatment. The vehicle may influence the dissociation of calcium hydroxide into ions. We sought to evaluate the level of pH and to quantitatively estimate the release of proteins, hydroxyproline, and phosphorus from pieces of radicular dentin kept in different Ca(OH)(2) solutions.
Twenty-eight extracted incisors were maintained for 35 days in Ca(OH)(2) aqueous solutions prepared in chlorhexidine digluconate, propylene glycol (PG), anesthetic solution, camphorated monochlorophenol (CMCP), and CMCP-PG. The control solution contained Ca(OH)(2) without vehicle.
The pH values changed little during the experiment. The concentrations of proteins, hydroxyproline, and phosphorus rose for all the solutions under study. Statistical analysis of the data from the control and the experimental groups revealed an increase in the concentration of proteins when chlorhexidine, anesthetic solution, and PG were used; a rise in hydroxyproline levels when CMCP-PG, CMCP, and PG solutions were used; and an increase in phosphorus when PG and chlorhexidine vehicles were used.
The test solutions with the root dentin remained alkaline. A release of proteins, hydroxyproline, and phosphorus was observed.
氢氧化钙[Ca(OH)₂]是一种常见的根管内用药。氢氧化钙粉末可与不同载体混合，用作根管内临时治疗的糊剂。载体可能会影响氢氧化钙解离成离子。我们试图评估pH值水平，并定量估计保存在不同氢氧化钙溶液中的牙根牙本质块中蛋白质、羟脯氨酸和磷的释放量。
将28颗拔除的切牙在葡萄糖酸洗必泰、丙二醇（PG）、麻醉溶液、樟脑对氯苯酚（CMCP）和CMCP - PG中制备的氢氧化钙水溶液中保存35天。对照溶液含有不含载体的氢氧化钙。
实验期间pH值变化不大。所有研究溶液中蛋白质、羟脯氨酸和磷的浓度均升高。对对照组和实验组数据的统计分析表明，使用洗必泰、麻醉溶液和PG时蛋白质浓度增加；使用CMCP - PG、CMCP和PG溶液时羟脯氨酸水平升高；使用PG和洗必泰载体时磷增加。
含牙根牙本质的测试溶液保持碱性。观察到蛋白质、羟脯氨酸和磷的释放。
