Grunenberg R, Menke-Möllers I, Krüger J
Institut für Transfusionsmedizin, Universität zu Köln, BRD.
Beitr Infusionsther. 1992;30:62-5.
From all blood donors screened within a given period of 6 months for SGPT (ALT) immediately before donation, 166 (141 male, 25 female) were found to have SGPT activities above our cutoff value of > 28 IU/l (25 degrees C). In order to define the characteristics of these blood donors they were asked for detailed medical history followed by a thorough physical examination and further serologic and biochemical testing. Factors associated with elevated SGPT activity included daily alcohol consumption (82 donors), infections associated with abnormal DCs (23), therapy with hepatotoxic drugs (8), infections that had been treated with antibiotics (6), strenuous physical exercises (5), body building supported by anabolics (2), acute HBV infection (1), acute HCV infection (1), alcohol/drug abuse and positive test for anti-HCV antibodies (1), anti-CMV positivity with absolute and relative lymphocytosis (1). In 36 cases factors that could have been associated with an increased SGPT activity were not verified. A critical valuation of the presently accepted cutoff value of 45 IU/l (25 degrees C) is given.
在6个月内接受献血前即刻SGPT（ALT）筛查的所有献血者中，发现166人（141名男性，25名女性）的SGPT活性高于我们设定的>28 IU/l（25℃）的临界值。为了明确这些献血者的特征，询问了他们详细的病史，随后进行了全面的体格检查以及进一步的血清学和生化检测。与SGPT活性升高相关的因素包括每日饮酒（82名献血者）、与异常DCs相关的感染（23例）、使用肝毒性药物治疗（8例）、曾用抗生素治疗的感染（6例）、剧烈体育锻炼（5例）、使用合成代谢类固醇辅助的健身（2例）、急性HBV感染（1例）、急性HCV感染（1例）、酒精/药物滥用且抗-HCV抗体检测阳性（1例）、抗CMV阳性伴绝对和相对淋巴细胞增多（1例）。36例中，未证实可能与SGPT活性升高相关的因素。对目前公认的45 IU/l（25℃）临界值进行了批判性评估。
