Tschen Eduardo, Jones Terry
Academic Dermatology Associates, Albuquerque, NM, USA.
J Drugs Dermatol. 2002 Sep;1(2):153-7.
Topical acne therapies are widely used for the treatment of mild to moderately severe acne vulgaris. However, many available treatments have limitations associated with their use, including lengthy time to response, cosmetic acceptability, and photosensitivity. Combinations of topical antibiotics and comedolytics are especially useful, but some formulations have stability challenges. A new combination formulation that contains 1% clindamycin and 5% benzoyl peroxide (BenzaClin Topical Gel) is currently available. In clinical trials, clinical improvement occurred at the first two follow-up visits and continued throughout treatment. In addition, combination therapy with clindamycin/benzoyl peroxide gel rapidly reduces Propionibacteria acnes counts and suppresses the emergence of clindamycin-resistant P. acnes. This formulation is stable at room temperature for up to 2 months after compounding. The aqueous gel vehicle is less drying, and there is no photosensitivity associated with its use. This study compares the combination treatment of 1% clindamycin and 5% benzoyl peroxide topical gel with other therapeutic options for mild to moderately severe acne vulgaris.
局部痤疮疗法被广泛用于治疗轻度至中度重度寻常痤疮。然而，许多现有的治疗方法在使用上存在局限性，包括起效时间长、美容可接受性以及光敏性。局部抗生素和角质剥脱剂的联合使用特别有效，但一些制剂存在稳定性问题。一种含有1%克林霉素和5%过氧化苯甲酰的新联合制剂（BenzaClin局部凝胶）目前已上市。在临床试验中，在前两次随访时就出现了临床改善，且在整个治疗过程中持续改善。此外，克林霉素/过氧化苯甲酰凝胶联合疗法可迅速减少痤疮丙酸杆菌数量，并抑制耐克林霉素痤疮丙酸杆菌的出现。该制剂在室温下配制后长达2个月内稳定。水性凝胶载体的干燥性较小，且使用时无光敏性。本研究比较了1%克林霉素和5%过氧化苯甲酰局部凝胶联合治疗与其他治疗轻度至中度重度寻常痤疮的方法。
