Dutil Maha
Division of Dermatology, University of Toronto, Women's College Hospital, Toronto, ON, Canada.
Skin Therapy Lett. 2010 Nov-Dec;15(10):5-7.
Benzoyl peroxide is one of the most widely used topical agents for acne. It has potent antibacterial and mild anti-inflammatory and comedolytic effects. To treat mild to moderate acne, it can be used alone or in combination with topical antibiotics and topical retinoids. The combination of benzoyl peroxide with either erythromycin or clindamycin is synergistic and well-tolerated. In more severe acne, when oral antibiotics are required, benzoyl peroxide can contribute to suppressing the emergence of resistant strains of Propionibacterium acnes.
过氧化苯甲酰是治疗痤疮最常用的外用药物之一。它具有强大的抗菌作用以及温和的抗炎和溶解粉刺作用。治疗轻至中度痤疮时，它可单独使用，也可与外用抗生素和外用维甲酸联合使用。过氧化苯甲酰与红霉素或克林霉素联合使用具有协同作用且耐受性良好。在更严重的痤疮中，当需要口服抗生素时，过氧化苯甲酰有助于抑制痤疮丙酸杆菌耐药菌株的出现。
