Del Rosso James
Valley Hospital Medical Center, Las Vegas, NV, USA.
J Drugs Dermatol. 2008 Feb;7(2 Suppl):s2-7.
Topical antimicrobial agents are commonly used as first-line agents for the management of mild to moderate acne vulgaris. Agents with antibacterial activity (eg, benzoyl peroxide and clindamycin), reduce counts of Propionibacterium acnes, while also decreasing the numbers of inflammatory and noninflammatory lesions. In order to optimize efficacy, topical antibiotics are most commonly used in combination with benzoyl peroxide, an approach which also reduces the emergence of strains of P acnes that are less sensitive to antibiotics. Other topical antiacne options include retinoids (with or without an antimicrobial agent), sulfacetamide, sulfacetamide-sulfur, and azelaic acid. Certain formulations of benzoyl peroxide offer improved tolerability, while a new micronized form may enhance efficacy by optimizing follicular penetration. This wide array of options allows dermatologists to tailor topical treatments to the needs of individual patients.
局部用抗菌剂通常作为治疗轻至中度寻常痤疮的一线药物。具有抗菌活性的药物（如过氧化苯甲酰和克林霉素）可减少痤疮丙酸杆菌数量，同时还能减少炎性和非炎性皮损的数量。为了优化疗效，局部用抗生素最常与过氧化苯甲酰联合使用，这种方法还能减少对抗生素敏感性较低的痤疮丙酸杆菌菌株的出现。其他局部抗痤疮药物包括维甲酸（含或不含抗菌剂）、磺胺醋酰、磺胺醋酰硫磺和壬二酸。某些过氧化苯甲酰制剂的耐受性有所改善，而一种新的微粉化形式可能通过优化毛囊渗透来提高疗效。如此广泛的选择使皮肤科医生能够根据个体患者的需求定制局部治疗方案。
