Krähenbühl S
Klinische Pharmakologie und Toxikologie, Universitätsspital, Basel.
Ther Umsch. 2003 Jun;60(6):335-40. doi: 10.1024/0040-5930.60.6.335.
Benzodiazepines and benzodiazepine-like substances belong to the drugs prescribed and consumed most frequently. While acute toxicity is low in comparison to other hypnotics, physical and psychological dependence can develop during continuous ingestion of these drugs over months. Withdrawal symptoms can therefore develop, if the ingestion of these drugs is stopped abruptly. If a withdrawal of benzodiazepines is considered, this should be discussed in detail with the patient and be performed gradually over months. Faster withdrawals or withdrawal in polytoxicomanic patients should be performed in a specialized unit. After a successful withdrawal, patients should have psychological support in order to prevent relapses.
苯二氮䓬类药物和苯二氮䓬样物质属于最常被处方和使用的药物。与其他催眠药相比,其急性毒性较低,但连续数月服用这些药物可能会产生身体和心理依赖。因此,如果突然停止服用这些药物,可能会出现戒断症状。如果考虑停用苯二氮䓬类药物,应与患者详细讨论,并在数月内逐渐进行。更快的撤药或在多药滥用患者中撤药应在专门的单位进行。成功撤药后,患者应获得心理支持以防止复发。