Iwan-Zietek I, Zietek Z, Kotschy M, Rość D, Tyloch F, Cwiklińska-Jurkowska M
Katedry i Kliniki Urologii AM, Bydgoszczy.
Pol Tyg Lek. 1992;47(49-50):1096-7.
An increased blood fibrinolytic activity manifested by increased tissue plasminogen activator (t-PA) and decreased tissue plasminogen activator inhibitor (PAI-1) and increased FDP levels are seen in 40 patients with mild hypertrophy of prostate. Surgical treatment increased blood fibrinolytic activity manifested in the increase in t-PA, decrease in PAI-1, shortening of ELT, increase in FDP, and decrease in plasminogen and 2-AP activities. Blood fibrinolytic activity was the highest immediately after surgery with tendency to the gradual normalization. Positive ethanol test and decrease in thrombocyte count indicate and activation of blood clotting system induced by the tissue thrombo-elastins released during surgery. Subclinical DCI with the secondary increased fibrinolysis activation is present in patients with mild hypertrophy of the prostate both prior to and after surgery.
40例轻度前列腺肥大患者可见血液纤溶活性增加，表现为组织纤溶酶原激活物（t-PA）增加、组织纤溶酶原激活物抑制剂（PAI-1）降低及纤维蛋白降解产物（FDP）水平升高。手术治疗使血液纤溶活性增加，表现为t-PA增加、PAI-1降低、优球蛋白溶解时间（ELT）缩短、FDP增加以及纤溶酶原和α2-抗纤溶酶（2-AP）活性降低。血液纤溶活性在术后即刻最高，有逐渐恢复正常的趋势。乙醇阳性试验及血小板计数降低表明手术过程中释放的组织凝血弹性蛋白酶诱导了凝血系统的激活。轻度前列腺肥大患者在手术前后均存在亚临床弥漫性脑缺血（DCI）并继发纤溶激活增加。
