Warner Timothy D, Mitchell Jane A
The William Harvey Research Institute, Barts and The London, Queen Mary's School of Medicine and Dentistry, Charterhouse Square, London EC1M 6BQ, UK.
Clin Sci (Lond). 2003 Oct;105(4):393-4. doi: 10.1042/CS20030208.
Mechanical forces are key regulators of cell function, particularly of cells within the arterial wall that are exposed to the shear stress and pulsatile pressure of flowing blood. The finding by Chang and colleagues in this issue of Clinical Science that cell stretch can up-regulate the expression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor, which is a key regulator of blood vessel remodelling, provides us with further insight into the mechanisms underlying remodelling at sites of occlusive disease within the cardiovascular system.
机械力是细胞功能的关键调节因子，对于动脉壁内暴露于流动血液的剪切应力和脉动压力的细胞而言尤其如此。Chang及其同事在本期《临床科学》上发表的研究发现，细胞拉伸可上调缺氧诱导因子-1α和血管内皮生长因子的表达，而血管内皮生长因子是血管重塑的关键调节因子，这为我们进一步深入了解心血管系统闭塞性疾病部位重塑的潜在机制提供了线索。
