Krediet R T, Imholz A L, Struijk D G, Koomen G C, Arisz L
Renal Unit Department of Medicine, Academic Medical Center, University of Amsterdam, The Netherlands.
Blood Purif. 1992;10(3-4):173-81. doi: 10.1159/000170044.
A review is given on various aspects of using the disappearance rate of intraperitoneally administered macromolecules for the determination of fluid kinetics in CAPD patients. The rationale and mathematics for the calculation of transcapillary ultrafiltration and of indirect measurement of lymphatic absorption are described. A comparison is made between autologous haemoglobin, human albumin and dextran 70. Dextran 70 appeared most useful; one brand of human albumin increased solute transport. Lymphatic absorption was higher after the installation of a 3-litre dialysate volume than after a 2-litre one, and also higher during peritonitis than after recovery from infection. A gradual increase in intraperitoneal volume, as obtained with glucose 3.86% dialysate, had no apparent effect on the disappearance rate of dextran 70. It is concluded that intraperitoneally administered dextran 70 is a clinically useful marker for the description of fluid kinetics in CAPD patients under various conditions.
本文综述了利用腹腔内注射大分子物质的消失率来测定持续性非卧床腹膜透析（CAPD）患者液体动力学的各个方面。描述了计算跨毛细血管超滤和间接测量淋巴吸收的原理及数学方法。对自体血红蛋白、人白蛋白和右旋糖酐70进行了比较。右旋糖酐70似乎最有用；一种品牌的人白蛋白会增加溶质转运。3升透析液容量灌注后淋巴吸收高于2升透析液容量灌注后，腹膜炎期间的淋巴吸收也高于感染恢复后。使用3.86%葡萄糖透析液导致腹腔内体积逐渐增加，对右旋糖酐70的消失率没有明显影响。得出结论，腹腔内注射右旋糖酐70是描述不同条件下CAPD患者液体动力学的一种临床有用标志物。
