Deisseroth Karl, Mermelstein Paul G, Xia Houhui, Tsien Richard W
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford CA 94305, USA.
Curr Opin Neurobiol. 2003 Jun;13(3):354-65. doi: 10.1016/s0959-4388(03)00076-x.
Signaling from synapse to nucleus is vital for activity-dependent control of neuronal gene expression and represents a sophisticated form of neural computation. The nature of specific signal initiators, nuclear translocators and effectors has become increasingly clear, and supports the idea that the nucleus is able to make sense of a surprising amount of fast synaptic information through intricate biochemical mechanisms. Information transfer to the nucleus can be conveyed by physical translocation of messengers at various stages within the multiple signal transduction cascades that are set in motion by a Ca(2+) rise near the surface membrane. The key role of synapse-to-nucleus signaling in circadian rhythms, long-term memory, and neuronal survival sheds light on the logical underpinning of these signaling mechanisms.
从突触到细胞核的信号传导对于神经元基因表达的活动依赖性控制至关重要，并且代表了一种复杂的神经计算形式。特定信号启动子、核转运体和效应器的性质已越来越清晰，这支持了细胞核能够通过复杂的生化机制理解大量快速突触信息的观点。信息向细胞核的传递可通过信使在多个信号转导级联反应的不同阶段进行物理转运来实现，这些级联反应由细胞膜附近Ca(2+)升高引发。突触到细胞核信号传导在昼夜节律、长期记忆和神经元存活中的关键作用揭示了这些信号传导机制的逻辑基础。
