Department of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, CA 90095-1737, United States.
Curr Opin Neurobiol. 2011 Apr;21(2):345-52. doi: 10.1016/j.conb.2011.01.011. Epub 2011 Feb 23.
Signals generated in distal subcellular compartments of neurons must often travel long distances to the nucleus to trigger changes in gene expression. This retrograde signaling is critical to the development, function, and survival of neural circuits, and neurons have evolved multiple mechanisms to transmit signals over long distances. In this review, we briefly summarize the range of mechanisms whereby distally generated signals are transported to neuronal nuclei. We then focus on the transport of soluble signals from the synapse to the nucleus during neuronal plasticity.
神经元远端亚细胞区室产生的信号必须长距离传递到细胞核，以触发基因表达的改变。这种逆行信号对于神经回路的发育、功能和存活至关重要，神经元已经进化出多种机制来远距离传递信号。在这篇综述中，我们简要总结了远处产生的信号被运输到神经元核的一系列机制。然后，我们将重点介绍神经元可塑性过程中从突触到细胞核的可溶性信号的运输。
