Nahm Moon H, Glezen Paul, Englund Janet
Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA.
Vaccine. 2003 Jul 28;21(24):3393-7. doi: 10.1016/s0264-410x(03)00340-2.
The repertoire of human antibodies to Haemophilus influenzae type b polysaccharide (Hib PS) has been extensively characterized. In response to Hib PS vaccines, both IgG1 and IgG2 antibodies are produced. Based on the Vkappa gene used for the antibodies, heamophilus antibodies can be divided into A2 and non-A2 antibodies. A2 antibodies account for the majority of heamophilus antibodies, are generally more functional, and are specific for heamophilus polysaccharide. In contrast, non-A2 antibodies cross-react with Escherichia coli K100. Studies of placental transfer showed that IgG1 antibodies cross the placenta better than IgG2 antibodies and the A2 antibodies better than non-A2 antibodies. Babies born to mothers who were immunized with a heamophilus vaccine had a high level of antibodies to Hib PS but the antibody level decreased during the first 6 months. The children also responded to a heamophilus conjugate vaccine.
针对b型流感嗜血杆菌多糖（Hib PS）的人类抗体库已得到广泛表征。针对Hib PS疫苗，会产生IgG1和IgG2抗体。根据抗体所使用的Vkappa基因，流感嗜血杆菌抗体可分为A2和非A2抗体。A2抗体占流感嗜血杆菌抗体的大多数，通常功能更强，且对流感嗜血杆菌多糖具有特异性。相比之下，非A2抗体与大肠杆菌K100发生交叉反应。胎盘转移研究表明，IgG1抗体比IgG2抗体更易穿过胎盘，A2抗体比非A2抗体更易穿过胎盘。接种流感嗜血杆菌疫苗的母亲所生婴儿具有高水平的Hib PS抗体，但抗体水平在头6个月内会下降。这些儿童对流感嗜血杆菌结合疫苗也有反应。
