Quiambao B P, Nohynek H, Käyhty H, Ollgren J, Gozum L, Gepanayao C P, Soriano V, Mäkela P H
Research Institute for Tropical Medicine, Alabang, Muntinlupa, Metro Manila 1781, Philippines.
Vaccine. 2003 Jul 28;21(24):3451-4. doi: 10.1016/s0264-410x(03)00349-9.
A randomized, controlled study was conducted to evaluate the immunogenicity and reactogenicity of the 23-valent pneumococcal (Pnc) polysaccharide (PS) vaccine among pregnant women and to ascertain the transfer of anti-Pnc antibody (Ab) from mother to infant. One hundred and sixty women received either one dose of Pnc PS vaccine, Haemophilus influenzae type b conjugate vaccine and tetanus toxoid (TT) (Pnc vaccine group, N=106) or TT only (control group, N=54). Sera were obtained from all mothers prior to vaccination and 4 weeks after from the vaccinated group. Cord blood was obtained in 75% of deliveries. Anti-Pnc Ab for serotypes 1, 5, 6B, 14, 18C and 19F was determined using enzyme immunoassay. The Pnc vaccine and control groups were comparable in terms of age, parity, gravidity, prior doses of TT, and pre-vaccination geometric mean concentration (GMC in microg/ml) of anti-Pnc Ab. Between 66 and 87% of the mothers had type-specific Ab prior to vaccination. There was a significant rise in anti-Pnc Ab (varying from 3.3- to 9.1-fold for the individual serotypes) between the pre and post-vaccination samples. Adverse reactions were mild and required no treatment. The level of anti-Pnc Ab in cord blood was significantly lower in the control group compared to the Pnc vaccine group. Vaccination of pregnant women with Pnc Ps vaccine induces good immune response and Ab can be transferred to their infants via cord blood thus providing enhanced protection.
进行了一项随机对照研究，以评估23价肺炎球菌（Pnc）多糖（PS）疫苗在孕妇中的免疫原性和反应原性，并确定抗Pnc抗体（Ab）从母亲到婴儿的传递情况。160名妇女分别接受一剂Pnc PS疫苗、b型流感嗜血杆菌结合疫苗和破伤风类毒素（TT）（Pnc疫苗组，N = 106）或仅接受TT（对照组，N = 54）。在接种疫苗前从所有母亲处采集血清，接种疫苗组在接种后4周采集血清。75%的分娩中采集了脐带血。使用酶免疫测定法测定血清型1、5、6B、14、18C和19F的抗Pnc Ab。Pnc疫苗组和对照组在年龄、产次、妊娠次数、既往TT剂量以及接种疫苗前抗Pnc Ab的几何平均浓度（GMC，单位为μg/ml）方面具有可比性。66%至87%的母亲在接种疫苗前具有型特异性Ab。接种疫苗前后样本之间抗Pnc Ab有显著升高（各血清型升高3.3至9.1倍不等）。不良反应轻微，无需治疗。与Pnc疫苗组相比，对照组脐带血中抗Pnc Ab水平显著较低。孕妇接种Pnc Ps疫苗可诱导良好的免疫反应，并且Ab可通过脐带血传递给婴儿，从而提供增强的保护。
