Katamine S, Tanaami S, Mamiya Y, Sekimoto K, Hoshino N, Totsuka K, Suzuki M
J Nutr Sci Vitaminol (Tokyo). 1985 Oct;31(5):541-51. doi: 10.3177/jnsv.31.541.
The effects of the feeding of high-iodine eggs to rats with an abnormal thyroid status were investigated. Rats were fed for one week on a commercial diet supplemented with propylthiouracil (PTU) (10 mg/100 g diet) or thyroxine-Na (240 micrograms/100 g diet) respectively, to induce hypo- or hyperthyroidism, and then further fed for 4 weeks on the respective drug-supplemented diets, containing 1% (w/w) of either ordinary or high-iodine egg powder. Control (euthyroid) rats were maintained on the commercial diet. The induction of a hypothyroid state resulted in thyroid hyperplasia, with decreased thyroid iodine content, altered serum thyroid relating hormone levels (increased TSH and decreased T3 and T4), elevated serum total cholesterol and reduced serum triacylglycerol (TG) levels, and also increased muscle and adipose tissue lipoprotein lipase (LPL) activities. In contrast, in the hyperthyroid animals, thyroid atrophy, as well as decreased serum TSH and increased T3 and T4 levels, was associated with reduced serum total cholesterol level and muscle LPL activity. There were no essential differences between animals given high-iodine and ordinary eggs in either hypo- or hyperthyroid state, although the effects of PTU treatment on the thyroid and serum TG level appeared to be slightly lesser in rats given high-iodine eggs than in those given ordinary eggs. It is concluded that high-iodine eggs did not have any side-effect on either hypo- or hyperthyroid rat in this study.
研究了给甲状腺功能异常的大鼠喂食高碘蛋的影响。分别用补充丙硫氧嘧啶（PTU）（10毫克/100克饲料）或甲状腺素钠（240微克/100克饲料）的商业饲料喂养大鼠一周，以诱导甲状腺功能减退或亢进，然后在各自补充药物的饲料上再喂养4周，饲料中含有1%（w/w）的普通或高碘蛋粉。对照（甲状腺功能正常）大鼠维持喂食商业饲料。甲状腺功能减退状态的诱导导致甲状腺增生，甲状腺碘含量降低，血清甲状腺相关激素水平改变（促甲状腺激素升高，三碘甲状腺原氨酸和甲状腺素降低），血清总胆固醇升高，血清三酰甘油（TG）水平降低，肌肉和脂肪组织脂蛋白脂肪酶（LPL）活性也增加。相反，在甲状腺功能亢进的动物中，甲状腺萎缩以及血清促甲状腺激素降低和三碘甲状腺原氨酸及甲状腺素水平升高与血清总胆固醇水平和肌肉LPL活性降低有关。在甲状腺功能减退或亢进状态下，喂食高碘蛋和普通蛋的动物之间没有本质区别，尽管在喂食高碘蛋的大鼠中，PTU治疗对甲状腺和血清TG水平的影响似乎比喂食普通蛋的大鼠略小。得出的结论是，在本研究中，高碘蛋对甲状腺功能减退或亢进的大鼠均无任何副作用。
