Lidegaard Øjvind
Danish Centre for Human Reproductive Epidemiology (DaHRE), Department of Obstetrics and Gynaecology, Herlev University Hospital, Copenhagen County, Denmark.
J Obstet Gynaecol Can. 2003 Jul;25(7):575-7. doi: 10.1016/s1701-2163(16)31016-7.
To achieve absolute risk estimates of venous thromboembolism (VTE) among women on cyproterone acetate plus ethinylestradiol (CPA/EE), and among women on combined oral contraceptives (COCs).
From the Danish National Register of Patients (NRP), 1996 to 1998, the records of 1.1 million Danish women, ages 15 to 44 years, were searched for evidence of VTE. COC use was ascertained through mailed questionnaires. Sales statistics of COCs and CPA/EE were provided through Danish Drug Statistics.
During the time frame of the study, 330 women were found to have had VTE while on COCs. Of these women, 67 were on levonorgestrel-containing COCs. Eleven were on CPA/EE. The corresponding absolute risk of VTE was 3.4 (range, 3.1-3.8) per 10 000 women years among the women on COCs, 4.2 (range, 3.2-5.2) per 10 000 women years among women on levonorgestrel-containing COCs, and 3.1 (range, 1.3-4.9) per 10 000 women years among the women on CPA/EE.
Our results suggest the absolute risk of VTE among Danish women on COCs is similar to that among women taking CPA/EE.
获得服用醋酸环丙孕酮加炔雌醇（CPA/EE）的女性以及服用复方口服避孕药（COC）的女性发生静脉血栓栓塞（VTE）的绝对风险估计值。
从丹麦国家患者登记处（NRP）检索1996年至1998年110万年龄在15至44岁的丹麦女性的记录，以寻找VTE的证据。通过邮寄问卷确定COC的使用情况。COC和CPA/EE的销售统计数据由丹麦药品统计提供。
在研究期间，发现330名女性在服用COC时发生了VTE。在这些女性中，67名服用含左炔诺孕酮的COC。11名服用CPA/EE。服用COC的女性中VTE的相应绝对风险为每10000妇女年3.4（范围3.1 - 3.8），服用含左炔诺孕酮COC的女性中为每10000妇女年4.2（范围3.2 - 5.2），服用CPA/EE的女性中为每
