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胎儿多普勒在产科中的应用。

The use of fetal Doppler in obstetrics.

作者信息

Gagnon Robert, Van den Hof Michiel

机构信息

Council of the Society of Obstetricians and Gynaecologists of Canada.

出版信息

J Obstet Gynaecol Can. 2003 Jul;25(7):601-14; quiz 615-6.

Abstract

OBJECTIVE

To develop national guidelines on the use of fetal Doppler in obstetrics.

OPTIONS

Whether umbilical cord artery, umbilical cord venous, ductus venosus, and middle cerebral artery Doppler are useful in assessing fetal health.

OUTCOME

Prediction of adverse perinatal outcome or prediction of fetal anemia.

EVIDENCE

MEDLINE search and review of bibliographies in identified articles.

VALUES

The evidence was reviewed by the Diagnostic Imaging Committee and the principal authors. A quality of evidence assessment was undertaken as outlined in the report of the Canadian Task Force on the Periodic Health Examination.

BENEFITS, HARMS, AND COSTS: Intrauterine growth restriction complicates 5% to 10% of all pregnancies and up to 30% of multiple pregnancies. In 60% of these pregnancies, the primary cause is placental insufficiency. Improvement in the identification of the fetus at risk of intrauterine demise may lead to more successful management strategies. Management of fetal red blood cell isoimmunization requires a prediction of fetal anemia. If invasive procedures to predict fetal anemia can be replaced with noninvasive tests, fetal morbidity and mortality can be reduced.

RECOMMENDATIONS

  1. Umbilical artery Doppler should be available for assessment of the fetal-placental circulation in pregnant women with suspected severe placental insufficiency. (I-A) 2. Depending on other clinical factors, reduced, absent, or reversed umbilical artery end-diastolic flow is an indication for enhanced fetal surveillance or delivery. If delivery is delayed to enhance fetal lung maturity with maternal administration of glucocorticoid, intensive fetal surveillance until delivery is suggested for those fetuses with reversed end-diastolic flow. (II-1B) 3. Umbilical artery Doppler should not be used as a screening tool in healthy pregnancies, as it has not been shown to be of value in this group. (I-A) 4. Umbilical venous double pulsations, in the presence of abnormal umbilical artery Doppler waveforms, necessitate a detailed assessment of fetal health status. (II-3B) 5. Measurement of the fetal middle cerebral artery Doppler peak systolic flow velocity is a predictor of moderate or severe fetal anemia and can be used to avoid unnecessary invasive procedures in pregnancies complicated with red blood cell isoimmunization. (II-1A) 6. Since inaccurate information concerning fetal Doppler studies could lead to inappropriate clinical decisions, it is imperative that measurements be undertaken and interpreted by expert operators who are knowledgeable about the significance of Doppler changes and who practise appropriate techniques. Duplex mode with pulsed Doppler and colour Doppler flow mapping is the minimum required ultrasound equipment. (II-1A)
摘要

目的

制定关于产科胎儿多普勒使用的国家指南。

选项

脐动脉、脐静脉、静脉导管及大脑中动脉多普勒在评估胎儿健康方面是否有用。

结果

预测围产期不良结局或预测胎儿贫血。

证据

通过MEDLINE检索及对已识别文章的参考文献进行综述。

价值观

证据由诊断成像委员会及主要作者进行审查。按照加拿大定期健康检查特别工作组报告中概述的方法进行证据质量评估。

益处、危害及成本:宫内生长受限在所有妊娠中占5%至10%,在多胎妊娠中高达30%。在这些妊娠中,60%的主要原因是胎盘功能不全。改善对有宫内死亡风险胎儿的识别可能会带来更成功的管理策略。胎儿红细胞同种免疫的管理需要预测胎儿贫血。如果能用非侵入性检测替代预测胎儿贫血的侵入性操作,则可降低胎儿发病率和死亡率。

建议

  1. 对于怀疑有严重胎盘功能不全的孕妇,应使用脐动脉多普勒评估胎儿 - 胎盘循环。(I - A)2. 根据其他临床因素,脐动脉舒张末期血流减少、消失或反向是加强胎儿监测或分娩的指征。如果为促进胎儿肺成熟而延迟分娩并给予母体糖皮质激素,对于舒张末期血流反向的胎儿,建议在分娩前进行强化胎儿监测。(II - 1B)3. 脐动脉多普勒不应作为健康妊娠的筛查工具,因为在该群体中未显示其具有价值。(I - A)4. 在脐动脉多普勒波形异常的情况下,脐静脉双搏动需要对胎儿健康状况进行详细评估。(II - 3B)5. 测量胎儿大脑中动脉多普勒收缩期峰值流速可预测中度或重度胎儿贫血,可用于避免在合并红细胞同种免疫的妊娠中进行不必要的侵入性操作。(II - 1A)6. 由于关于胎儿多普勒研究的不准确信息可能导致不适当的临床决策,必须由熟悉多普勒变化意义并采用适当技术的专业操作人员进行测量和解读。带有脉冲多普勒和彩色多普勒血流成像的双功模式是所需的最低限度超声设备。(II - 1A)

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