Sprygin V G, Kushnerova N F, Rakhmanin Iu A
Gig Sanit. 2003 May-Jun(3):57-60.
The effect of a set of oligomeric anthocyanidins, isolated from viburnum, produced on the indices of lipid metabolism, lipid peroxidation (LPO) and on the hepatic antioxidant system in rats, who were subjected to the impact of carbon tetrachloride (CTC), was studied versus such effect exerted by preparations "Piknogenol" and "Legalon". The set of oligomeric anthocyanidins had a pronounced antitoxic and antioxidant action preventing the development of fat infiltration of the liver. The discussed preparation inhibited the processes of LPO, it normalized the level of antiradical hepatic activity and had a pronounced glutathione-saving effect, which is preconditioned by the biological activity of oligomeric anthocyanidins (traps for free radicals). The preparation can be used in prevention and treatment of toxic hepatic lesions.
研究了从荚蒾中分离出的一组低聚花青素对四氯化碳（CTC）作用下大鼠脂质代谢指标、脂质过氧化（LPO）及肝脏抗氧化系统的影响，并与制剂“碧萝芷”和“水飞蓟宾葡甲胺片”的作用进行对比。该组低聚花青素具有显著的抗毒和抗氧化作用，可防止肝脏脂肪浸润的发展。所讨论的制剂抑制了LPO过程，使肝脏抗自由基活性水平恢复正常，并具有显著的谷胱甘肽节省效应，这是由低聚花青素的生物活性（自由基捕获剂）所决定的。该制剂可用于预防和治疗中毒性肝损伤。
