早期年龄相关性黄斑变性患者中心视网膜的暗适应敏感性
Scotopic sensitivity of central retina in early age-related macular degeneration.
作者信息
Chen Changzheng, Wu Lezheng, Jiang Futian, Liang Jiongji, Wu De-Zheng
机构信息
Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China.
出版信息
Yan Ke Xue Bao. 2003 Mar;19(1):15-9.
PURPOSE
To test scotopic sensitivity and investigate whether there is rod system dysfunction in the central retina in early age-related macular degeneration (AMD).
METHODS
Scotopic (450 nm stimulus) and photopic (white light stimulus) sensitivity in 24 patients with early AMD was measured at 81 loci in central 25 degrees of retina, and compared with the age-match normal controls.
RESULTS
Mean scotopic sensitivity of AMD patients was significantly lower than that of the normal controls. The patients of reduced scotopic sensitivity were more than those of reduced photopic sensitivity. Scotopic sensitivity deficit decreased with increasing eccentricity with the greatest deficit was 2.5 degrees to 5.0 degrees.
CONCLUSIONS
Scotopic sensitivity was decreased in the early stage of AMD. The parafoveal rod cells were selectively damaged in AMD. Scotopic sensitivity testing in macula may be a useful tool to diagnose and measure the fundus dysfunction of AMD.
目的
测试暗视觉敏感性，并调查在早期年龄相关性黄斑变性（AMD）中，中央视网膜是否存在视杆系统功能障碍。
方法
测量了24例早期AMD患者在视网膜中央25度范围内81个位点的暗视觉（450纳米刺激）和明视觉（白光刺激）敏感性，并与年龄匹配的正常对照组进行比较。
结果
AMD患者的平均暗视觉敏感性显著低于正常对照组。暗视觉敏感性降低的患者多于明视觉敏感性降低的患者。暗视觉敏感性缺陷随着偏心度增加而降低，最大缺陷出现在2.5度至5.0度处。
结论
AMD早期暗视觉敏感性降低。AMD患者黄斑旁视杆细胞被选择性损伤。黄斑区暗视觉敏感性测试可能是诊断和测量AMD眼底功能障碍的有用工具。
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