Rosli Y, Bedford S M, James A C, Maddess T
Program of Biomedical Science, School of Diagnostic and Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur, Malaysia.
Vision Res. 2012 Sep 15;69:42-8. doi: 10.1016/j.visres.2012.07.019. Epub 2012 Aug 7.
We compared photopic and scotopic multifocal pupillographic stimuli in age-related macular degeneration (AMD). Both eyes of 18 normal and 14 AMD subjects were tested with four stimulus variants presented at photopic and 126 times lower luminances. The multifocal stimuli presented 24 test regions/eye to the central 60°. The stimulus variants had two different check sizes, and when presented either flickered (15 Hz) for 266 ms, or were steady for 133 ms. Mean differences from normal of 5 to 7 dB were observed in the central visual field for both photopic and scotopic stimuli (all p < 0.00002). The best areas under receiver operating characteristic plots for exudative AMD in the photopic and scotopic conditions were 92.9 ± 8.0 and 90.3 ± 5.7% respectively, and in less severely affected eyes 83.8 ± 9.7% and 76.9 ± 8.2%. Damage recorded at photopic levels was possibly more diffusely distributed across the visual field. Sensitivity and specificity was similar at photopic and scotopic levels.
我们比较了年龄相关性黄斑变性（AMD）患者明视和暗视条件下的多焦点瞳孔造影刺激。对18名正常受试者和14名AMD患者的双眼进行测试，使用四种刺激变体，分别在明视条件下以及亮度低126倍的暗视条件下呈现。多焦点刺激向中央60°的区域每只眼睛呈现24个测试区域。刺激变体有两种不同的方格大小，呈现时要么闪烁（15赫兹）266毫秒，要么稳定显示133毫秒。在中央视野中，明视和暗视刺激与正常情况相比的平均差异均为5至7分贝（所有p<0.00002）。在明视和暗视条件下，渗出性AMD患者在接受者操作特征曲线下的最佳面积分别为92.9±8.0%和90.3±5.7%，在病情较轻的眼睛中分别为83.8±9.7%和76.9±8.2%。在明视水平记录到的损伤可能在视野中分布得更分散。明视和暗视水平下的敏感性和特异性相似。
