Nebbioso Marcella, Barbato Andrea, Pescosolido Nicola
Department of Sense Organs, Faculty of Medicine and Odontology, Policlinico Umberto I, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy ; Department of Sense Organs, Ocular Electrophysiology Center, Sapienza University of Rome, Viale del Policlinico 155, 00161 Rome, Italy.
Department of Sense Organs, Faculty of Medicine and Odontology, Policlinico Umberto I, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy.
Biomed Res Int. 2014;2014:671529. doi: 10.1155/2014/671529. Epub 2014 Dec 9.
Recent clinical studies have shown that, in some degenerative retinal diseases, like age-related macular degeneration (AMD), the sensitivity of the rods decreases more rapidly than the sensitivity of the cones. The aim of this study was to evaluate if there is a correlation between the presence of hard drusen at the macular level and the rod damage responsible for the reduction in scotopic retinal sensitivity in subjects at risk for AMD.
The authors selected 24 subjects (14 men and 10 women) with an average age of 67.25 ± 5.7 years. Macular hard drusen were present in 50% of the subjects at the fundus oculi exam. The researchers evaluated the retinal sensitivity to light in mesopic and scotopic conditions of each subject with an MP-1 scotopic microperimeter (MP-1S).
In subjects with hard drusen in the fundus oculi examination, there was a statistically significant reduction in scotopic retinal sensitivity, while the mesopic retinal sensitivity was not compromised.
This study revealed how the presence of hard drusen at the macular level is associated with a reduction in scotopic retinal sensitivity compared to a control group of healthy subjects. Retinal functionality in a scotopic setting examined with MP-1S could be useful in early diagnosis of AMD.
近期临床研究表明，在一些退行性视网膜疾病中，如年龄相关性黄斑变性（AMD），视杆细胞的敏感性比视锥细胞的敏感性下降得更快。本研究的目的是评估黄斑区硬性玻璃膜疣的存在与导致AMD高危受试者视网膜暗视敏感性降低的视杆细胞损伤之间是否存在相关性。
作者选取了24名受试者（14名男性和10名女性），平均年龄为67.25±5.7岁。在眼底检查中，50%的受试者存在黄斑硬性玻璃膜疣。研究人员使用MP-1暗视微视野计（MP-1S）评估了每个受试者在中间视觉和暗视条件下对光的视网膜敏感性。
在眼底检查发现有硬性玻璃膜疣的受试者中，视网膜暗视敏感性有统计学意义的降低，而中间视觉视网膜敏感性未受影响。
本研究揭示了与健康受试者对照组相比，黄斑区硬性玻璃膜疣的存在与视网膜暗视敏感性降低有关。用MP-1S检查暗视环境下的视网膜功能可能有助于AMD的早期诊断。
