Yeh Jing-Ruey J, Crews Craig M
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA.
Dev Cell. 2003 Jul;5(1):11-9. doi: 10.1016/s1534-5807(03)00200-4.
Recent advances in cell and molecular biology have generated important tools to probe developmental questions. In addition, new genetic model systems such as Danio rerio now make large-scale vertebrate early developmental mutant screens feasible. Nonetheless, some developmental questions remain difficult to study because of the need for finer temporal, spatial, or tuneable control of gene function within a developmental system. New uses for old teratogens as well as novel chemical modulators of development have begun to fill this void.
细胞与分子生物学的最新进展为探究发育问题提供了重要工具。此外，诸如斑马鱼等新的遗传模型系统使得大规模脊椎动物早期发育突变体筛选成为可能。尽管如此，由于需要在发育系统内对基因功能进行更精细的时间、空间或可调控控制，一些发育问题仍然难以研究。旧致畸剂的新用途以及新型发育化学调节剂已开始填补这一空白。
