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[嗜铬细胞瘤的当前管理:约50例]

[Current management of pheochromocytoma: about 50 cases].

作者信息

Cherki S, Causeret S, Lifante J C, Mabrut J Y, Sin S, Berger N, Peix J L

机构信息

Service de chirurgie générale, hôpital de l'Antiquaille, 1, rue de l'Antiquaille, 69321 cedex 05, Lyon, France.

出版信息

Ann Chir. 2003 May;128(4):232-6. doi: 10.1016/s0003-3944(03)00065-8.

Abstract

STUDY AIM

The aim of this retrospective study was to assess our experience of the laparoscopic surgery of pheochromocytoma. We report indications and results of laparoscopic and open adrenalectomy for pheochromocytoma.

PATIENTS AND METHODS

Between january 1994 and may 2002, 50 patients underwent laparoscopic or open adrenalectomy for pheocromocytoma. The perioperative hemodynamic parameters were assessed for each patient. In each case, urinary metanephrine levels were measured at the second month postoperatively. The long term outcome was assessed in 44 patients. The mean follow-up was 39 months.

RESULTS

Ten patients underwent open adrenalectomy: 8 patients for unilateral tumors (tumor size was > 8 cm in 7 cases) and 2 patients for bilateral tumors (1 recurrence and 1 cystic polylobed tumor). Fourty patients underwent laparoscopic adrenalectomy: in 32 cases, including 1 patient with a bilateral tumor, no conversion was performed (tumor size was < 5 cm in 29 cases). In 8 cases (20%), a conversion to an open operation was performed. The reasons to convert were bleeding and periadrenal fibrosis in 7 cases. In laparoscopic adrenalectomy group, hemodynamic troubles were not more frequent, the hospital stay was shorter and there was no recurrence.

CONCLUSION

Laparoscopic adrenalectomy is the Gold standard procedure for patients with pheochromocytoma. But open adrenalectomy is sometimes indicated: tumor size > 8 cm, periadrenal fibrosis, and recurrence tumor.

摘要

研究目的

本回顾性研究旨在评估我们在嗜铬细胞瘤腹腔镜手术方面的经验。我们报告嗜铬细胞瘤腹腔镜肾上腺切除术和开放性肾上腺切除术的适应症及结果。

患者与方法

1994年1月至2002年5月期间,50例患者接受了嗜铬细胞瘤的腹腔镜或开放性肾上腺切除术。对每位患者的围手术期血流动力学参数进行评估。在每种情况下,术后第二个月测量尿间甲肾上腺素水平。对44例患者进行了长期随访。平均随访时间为39个月。

结果

10例患者接受了开放性肾上腺切除术:8例为单侧肿瘤(7例肿瘤大小>8 cm),2例为双侧肿瘤(1例复发,1例囊性多叶肿瘤)。40例患者接受了腹腔镜肾上腺切除术:32例,包括1例双侧肿瘤患者,未进行中转(29例肿瘤大小<5 cm)。8例(20%)进行了中转开腹手术。中转原因7例为出血和肾上腺周围纤维化。在腹腔镜肾上腺切除术组中,血流动力学问题并不更频繁,住院时间更短且无复发。

结论

腹腔镜肾上腺切除术是嗜铬细胞瘤患者的金标准手术。但有时需要进行开放性肾上腺切除术:肿瘤大小>8 cm、肾上腺周围纤维化和复发性肿瘤。

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