Adám E, Nász I, Lengyel A
Institute of Microbiology, Semmelweis University Medical School, Budapest, Hungary.
Acta Microbiol Hung. 1992;39(3-4):309-16.
Epitope composition of human adenovirus (AV) serotype 13 (subgenus A), 19, 26 and 27 (subgenus D), as well as 41 (subgenus F) was studied with 23 selected monoclonal antibodies (MAbs) raised against different hexon types. With the help of three panels of MAbs great differences were shown in the epitope structure of subgenus D hexons. Comparing two AV13 strain hexons (a prototype strain and an intermediate strain), it was shown that the epitopes recognized by the MAbs were present in different combinations even on strains of the same serotype. Therefore the epitope composition of the subgenus D hexons seems to be heterogeneous.
利用针对不同六邻体类型产生的23种选定单克隆抗体（MAb），研究了13型（A亚属）、19型、26型和27型（D亚属）以及41型（F亚属）人腺病毒（AV）的表位组成。借助三组单克隆抗体，发现D亚属六邻体的表位结构存在很大差异。比较两种AV13菌株的六邻体（一个原型菌株和一个中间菌株），结果表明，即使在同一血清型的菌株上，单克隆抗体识别的表位也以不同组合存在。因此，D亚属六邻体的表位组成似乎是异质的。
