Xu M, Shibayama H, Kobayashi H, Yamada K, Ishihara R, Zhao P, Takeuchi T, Yoshida K, Inagaki T, Nokura K
Department of Psychiatry, Nagoya University School of Medicine, Japan.
Acta Neuropathol. 1992;85(1):1-9. doi: 10.1007/BF00304627.
The occurrence and topographic analysis of granulovacuolar degeneration (GVD) in the hippocampal cortex of mentally normal controls (75 cases) and patients with Alzheimer's dementia (AD; 17 cases which included Alzheimer's disease and senile dementia of Alzheimer type), multi-infarct dementia (MID; 16 cases), Pick's disease (PD; 5 cases) and atypical dementia [5 cases; non-Alzheimer, non-Pick dementia with Fahr's syndrome (NANPDF)] were investigated. GVD was rarely found in control cases below the age of 60 years. In elderly normal brains, the statistically most representative ranking order of predilection for GVD (in decreasing severity) was: in the 60 s, CA1 > prosubiculum > CA2 (no GVD was found in the CA3 and CA4); in the 70 s, CA1 > prosubiculum > CA2 > CA3 > CA4; in the 80 s, CA1 > prosubiculum > CA2 > CA3 > CA4; in the 90 s, CA1 > prosubiculum > CA2 > CA3 > CA4. In the brains of demented patients, the rank order for GVD was: for AD, CA1 > CA2 > CA3 > prosubiculum > CA4; for MID, CA1 > prosubiculum > CA2 > CA3 > CA4; for PD, CA1 > CA2 > CA3 > prosubiculum > CA4; and for atypical dementia (NANPDF), CA1 > CA2 > prosubiculum > CA3 > CA4. The similarity of the predilection to ranking order was noted both in normal aged subjects and in MID as well as both in AD and in PD.(ABSTRACT TRUNCATED AT 250 WORDS)
对75例精神正常对照者、17例阿尔茨海默病痴呆患者（包括阿尔茨海默病和阿尔茨海默型老年痴呆）、16例多发梗死性痴呆患者、5例匹克病患者以及5例非典型痴呆患者（非阿尔茨海默病、非匹克病痴呆合并 Fahr 综合征）海马皮质中的颗粒空泡变性（GVD）的发生情况及地形分析进行了研究。60岁以下的对照病例中很少发现GVD。在老年正常大脑中按GVD偏好程度（从严重程度递减）统计最具代表性的排序为：60多岁时，CA1＞副海马体＞CA2（CA3和CA4未发现GVD）；70多岁时，CA1＞副海马体＞CA2＞CA3＞CA4；80多岁时，CA1＞副海马体＞CA2＞CA3＞CA4；90多岁时, CA1＞副海马体＞CA2＞CA3＞CA4。在痴呆患者大脑中，GVD的排序为：阿尔茨海默病，CA1＞CA2＞CA3＞副海马体＞CA4；多发梗死性痴呆，CA1＞副海马体＞CA2＞CA3＞CA4；匹克病，CA1＞CA2＞CA3＞副海马体＞CA4；非典型痴呆（非阿尔茨海默病非匹克病痴呆合并 Fahr 综合征），CA1＞CA2＞副海马体＞CA3＞CA4。在正常老年受试者和多发梗死性痴呆患者以及阿尔茨海默病患者和匹克病患者中均注意到偏好排序的相似性。（摘要截断于250字）
