Reed Terry, Dick Danielle M
Department of Medical & Molecular Genetics, Indiana University School of Medicine, Indianapolis 46202, USA.
Twin Res. 2003 Jun;6(3):227-34. doi: 10.1375/136905203765693889.
The authors define a trait "wellness" for good health in 6109 men in the National Academy of Sciences-National Research (NAS-NRC) twin panel aged 70 years and up surveyed by mail in the fall of 1998. Men who responded that they had not had a heart attack, coronary surgery, stroke, diabetes or prostate cancer in the survey questionnaire (Q8) met the broad definition of wellness. A more narrow definition included the absence of hypertension. Genetic analysis indicated that over 50% of the population variance for liability to either wellness definition was genetic. A subset of the NAS-NRC twins also participates in the National Heart, Lung and Blood Institute (NHLBI) twin study. NHLBI examinations and medical record review was done in 1986-1987 and 1995-1997 for 389 individuals who completed Q8. Excellent agreement (kappa > 0.8) was found between Q8 and outcome review for each condition comprising the wellness definition, ranging from 0.81 for coronary surgery to 0.88 for diabetes. Substantial agreement (kappa = 0.67) was found for hypertension. Kappa values for wellness were 0.82 for the broader definition and 0.74 if high blood pressure was included. Fraternal twin-pairs concordant for the wellness definitions are currently being recruited for linkage studies.
作者针对1998年秋季通过邮件调查的美国国家科学院 - 国家研究委员会（NAS - NRC）双生子队列中6109名70岁及以上男性的良好健康状况定义了一种特质“健康”。在调查问卷（问题8）中回答自己未曾患过心脏病、接受过冠状动脉手术、中风、糖尿病或前列腺癌的男性符合健康的宽泛定义。更狭义的定义还包括没有高血压。基因分析表明，对于这两种健康定义的易感性，超过50%的群体变异是由基因决定的。NAS - NRC双生子队列中的一部分人也参与了美国国立心肺血液研究所（NHLBI）的双生子研究。对389名完成问题8的个体在1986 - 1987年以及1995 - 1997年进行了NHLBI检查和病历审查。对于构成健康定义的每种疾病，在问题8与结果审查之间发现了高度一致性（kappa>0.8），冠状动脉手术的一致性为0.81，糖尿病为0.88不等。对于高血压，发现了实质性一致性（kappa = 0.67）。宽泛定义的健康状况的kappa值为0.82，若包括高血压则为0.74。目前正在招募在健康定义上一致的异卵双生子对进行连锁研究。
