Department of Surgical Oncology, Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, Zhejiang 310009, China.
Cancer Institute (Key Laboratory of Cancer Prevention &Intervention, National Ministry of Education, Provincial Key Laboratory of Molecular Biology in Medical Sciences), Second Affiliated Hospital, Zhejiang University School of Medicine, No. 88, Jiefang Road, Hangzhou, Zhejiang 310009, China.
Sci Rep. 2017 Jan 4;7:39786. doi: 10.1038/srep39786.
S100 family genes encode low molecular weight, acidic-Ca binding proteins implicating in a wide spectrum of biological processes. S100 family contains at least 20 members, most of which are frequently dysregulated in human malignancies including breast cancer. However, the prognostic roles of each individual S100, especially the mRNA level, in breast cancer patients remain elusive. In the current study, we used "The Kaplan-Meier plotter" (KM plotter) database to investigate the prognostic values of S100 mRNA expression in breast cancer. Our results indicated that high mRNA expression of S100A8, S100A9, S100A11 and S100P were found to be significantly correlated to worse outcome, while S100A1 and S100A6 were associated with better prognosis in all breast cancer patients. We further assessed the prognostic value of S100 in different intrinsic subtypes and clinicopathological features of breast cancer. The associated results will elucidate the role of S100 in breast cancer and may further lead the research to explore the S100-targeting reagents for treating breast cancer patients.
S100 家族基因编码低分子量、酸性钙结合蛋白，参与广泛的生物学过程。S100 家族至少包含 20 个成员，其中大多数在包括乳腺癌在内的人类恶性肿瘤中经常失调。然而，每个 S100 蛋白的预后作用，特别是在乳腺癌患者中的 mRNA 水平，仍然难以捉摸。在本研究中，我们使用“Kaplan-Meier plotter”（KM plotter）数据库来研究 S100 mRNA 表达在乳腺癌中的预后价值。我们的结果表明，S100A8、S100A9、S100A11 和 S100P 的高 mRNA 表达与不良预后显著相关，而 S100A1 和 S100A6 与所有乳腺癌患者的较好预后相关。我们进一步评估了 S100 在乳腺癌不同内在亚型和临床病理特征中的预后价值。相关结果将阐明 S100 在乳腺癌中的作用，并可能进一步促使研究探索针对 S100 的靶向试剂来治疗乳腺癌患者。
