Nickoloff B J
Department of Pathology, University of Michigan Medical School, Ann Arbor.
Arch Dermatol Res. 1992;284 Suppl 1:S10-1. doi: 10.1007/BF00638233.
For the better part of the past century, dermatologists have regarded the skin primarily as a large protective coat. Epidermal keratinocytes were highlighted for their production of keratins and lipids, which contributed to the structural integrity and barrier formation of skin. This "saran-wrap" perspective of skin mentioned keratinocytes only in cutaneous inflammatory reactions as passive targets for damaging diffusion products of infiltrating leukocytes. However, sufficient compelling in vitro and in vivo evidence is rapidly accumulating to support the novel perspective that epidermal keratinocytes can initiate and actively participate in the perpetuation of numerous cutaneous inflammatory reactions that involve a highly diverse array of inciting agents. This presentation emphasizes the keratinocyte and highlights the dynamic immunomodulatory capacity of this overlooked epidermal cell.
在过去一个世纪的大部分时间里，皮肤科医生主要将皮肤视为一层巨大的保护外衣。表皮角质形成细胞因其产生角蛋白和脂质而受到关注，这些物质有助于皮肤的结构完整性和屏障形成。这种对皮肤的“保鲜膜”观点认为，角质形成细胞仅在皮肤炎症反应中作为浸润白细胞损伤扩散产物的被动靶点。然而，越来越多充分且有说服力的体外和体内证据支持了一种新观点，即表皮角质形成细胞可以启动并积极参与许多涉及多种刺激因素的皮肤炎症反应的持续过程。本报告强调角质形成细胞，并突出这种被忽视的表皮细胞的动态免疫调节能力。
