Rösler Annette, Klok Harm-Anton, Hamley Ian W, Castelletto Valeria, Mykhaylyk Oleksandr O
Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
Biomacromolecules. 2003 Jul-Aug;4(4):859-63. doi: 10.1021/bm034058s.
This paper discusses the solid state and melt nanoscale structure of a series of novel poly(ethylene glycol) (PEG) hybrid di- and triblock copolymers, which contain amphiphilic beta-strand peptide sequences. The block copolymers have been prepared via solid-phase synthesis, affording perfectly monodisperse peptide segments with a precisely defined alpha-amino acid sequence. Attenuated total reflection Fourier transform infrared spectroscopy and X-ray scattering experiments indicate that the self-assembly properties of the peptide sequences are retained upon conjugation to PEG and mediate the formation of an ordered superstructure consisting of alternating PEG layers and peptide domains with an highly organized antiparallel beta-sheet structure. The results suggest that combination of biological structural motifs with synthetic polymers may be a versatile strategy for the development of novel self-assembled materials with complex internal structures and the potential to interface with biology.
本文讨论了一系列新型聚乙二醇（PEG）杂化二嵌段和三嵌段共聚物的固态和熔体纳米级结构，这些共聚物包含两亲性β-链肽序列。通过固相合成制备了嵌段共聚物，得到了具有精确确定的α-氨基酸序列的完美单分散肽段。衰减全反射傅里叶变换红外光谱和X射线散射实验表明，肽序列与PEG共轭后仍保留其自组装特性，并介导形成由交替的PEG层和具有高度有序反平行β-折叠结构的肽域组成的有序超结构。结果表明，将生物结构基序与合成聚合物相结合可能是开发具有复杂内部结构且具有与生物学相互作用潜力的新型自组装材料的通用策略。
