[Relation between nitric oxide synthase, psychology, gastric mucosal blood flow and gastric mucosal adaptive cytoprotection under stress in rats].

OBJECTIVE

To explore the relation between nitric oxide synthase (NOS), psychology, gastric mucosal blood flow(GMBF) and gastric mucosal adaptive cytoprotection under stress in rats and its possible mechanism.

METHODS

Animal model was constructed with impulsive stimulator of high voltage and stable currency, seventy-two male SD rats were randomly divided into three groups: control(C), regular(R) and irregular(I) group. NOS activity was measured by spectrophotometry and injure of gastric mucosa was measured by method of Nils Lambecht, GMBF was measured by LDF-3 flowmeter.

RESULTS

In both R group and I group, NOS increased significantly, but injury index(II) was on contrary apparently decreasing. GMBF was increased gradually after stress. In R group, there was a negative proportion between II and GMBF, in I group, there was a negative proportion between II and GMBF and NOS, but there was a positive relationship between NOS and GMBF.

CONCLUSION

NOS, psychology and GMBF all might participate in the course of the gastric mucosal adaptive cytoprotection under stress.