暴露于（1→3）-β-D-葡聚糖气雾剂的小鼠出现轻微呼吸道刺激但无炎症。
Slight respiratory irritation but not inflammation in mice exposed to (1-->3)-beta-D-glucan aerosols.
作者信息
Korpi A, Kasanen J-P, Kosma V-M, Rylander R, Pasanen A-L
机构信息
Department of Environmental Sciences University of Kuopio Neulaniementie 2 70211 P.O. Box 1627 Kuopio.
出版信息
Mediators Inflamm. 2003 Jun;12(3):139-46. doi: 10.1080/0962935031000134851.
Airway irritation effects after single and repeated inhalation exposures to aerosols of beta-glucan (grifolan) were investigated in mice. In addition, the effects on serum total immunoglobulin E (IgE) production and histopathological inflammation in the respiratory tract were studied. The beta-glucan aerosols provoked slight sensory irritation in the airways, but the response was not concentration dependent at the levels studied. Slight pulmonary irritation was observed after repeated exposures. No effect was found on the serum total IgE levels, and no signs of inflammation were seen in the airways 6 h after the final exposure. The results suggest that, irrespective of previous fungal sensitization of the animals, inhaled beta-glucan may cause symptoms of respiratory tract irritation but without apparent inflammation. Respiratory tract irritation reported after inhalation of fungi may not be entirely attributed to beta-glucan.
在小鼠中研究了单次和重复吸入β-葡聚糖（灰树花多糖）气雾剂后的气道刺激作用。此外，还研究了对血清总免疫球蛋白E（IgE）产生及呼吸道组织病理学炎症的影响。β-葡聚糖气雾剂引起气道轻微的感觉刺激，但在所研究的浓度水平下，反应不呈浓度依赖性。重复暴露后观察到轻微的肺部刺激。血清总IgE水平未发现有影响，末次暴露6小时后气道未见炎症迹象。结果表明，无论动物先前是否对真菌致敏，吸入β-葡聚糖可能会引起呼吸道刺激症状，但无明显炎症。吸入真菌后报告的呼吸道刺激可能并非完全归因于β-葡聚糖。
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