氨基糖苷类药物的多功能性及其未来前景。
Versatility of aminoglycosides and prospects for their future.
作者信息
Vakulenko Sergei B, Mobashery Shahriar
机构信息
Department of Chemistry, Wayne State University, Detroit, Michigan 48202, USA.
出版信息
Clin Microbiol Rev. 2003 Jul;16(3):430-50. doi: 10.1128/CMR.16.3.430-450.2003.
Abstract
Aminoglycoside antibiotics have had a major impact on our ability to treat bacterial infections for the past half century. Whereas the interest in these versatile antibiotics continues to be high, their clinical utility has been compromised by widespread instances of resistance. The multitude of mechanisms of resistance is disconcerting but also illuminates how nature can manifest resistance when bacteria are confronted by antibiotics. This article reviews the most recent knowledge about the mechanisms of aminoglycoside action and the mechanisms of resistance to these antibiotics.
摘要
在过去的半个世纪里，氨基糖苷类抗生素对我们治疗细菌感染的能力产生了重大影响。尽管人们对这些多功能抗生素的兴趣依然浓厚，但它们的临床效用却因广泛存在的耐药情况而大打折扣。众多的耐药机制令人担忧，但也揭示了细菌在面对抗生素时，自然界是如何表现出耐药性的。本文综述了关于氨基糖苷类抗生素作用机制以及对这些抗生素耐药机制的最新知识。
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