Bukari Zubeiru, Emmanuel Toyin, Woodward Jude, Ferguson Richard, Ezughara Martha, Darga Nikhil, Lopes Bruno Silvester
School of Health and Life Sciences, Teesside University, Middlesbrough TS1 3BX, UK.
National Horizons Centre, Teesside University, Darlington DL1 1HG, UK.
Trop Med Infect Dis. 2025 Jan 16;10(1):25. doi: 10.3390/tropicalmed10010025.
Antimicrobial resistance (AMR) in species, particularly and , poses a significant public health threat. These bacteria, which are commonly found in livestock, poultry, companion animals, and wildlife, are the leading causes of foodborne illnesses, often transmitted through contaminated poultry. Extensive exposure to antibiotics in human and veterinary medicine creates selection pressure, driving resistance through mechanisms such as point mutations, horizontal gene transfer, and efflux pumps. Resistance to fluoroquinolones, macrolides, and tetracyclines complicates treatment and increases the risk of severe infections. Drug-resistant is transmitted to humans via contaminated food, water, and direct contact with animals, highlighting its zoonotic potential. Addressing this challenge requires effective interventions. Pre-harvest strategies like biosecurity and immune-based methods reduce bacterial loads on farms, while post-harvest measures, including carcass decontamination and freezing, limit contamination. Emerging approaches, such as bacteriocins and natural antimicrobials, offer chemical-free alternatives. Integrated, multidisciplinary interventions across the food chain are essential to mitigate AMR transmission and enhance food safety. Sustainable agricultural practices, antimicrobial stewardship, and innovative solutions are critical to curbing resistance and protecting global public health. Our review examines the dynamics of antimicrobial resistance in and presents current strategies to mitigate -related AMR, offering valuable insights for antimicrobial control in the poultry industry.
某些物种，特别是[具体物种1]和[具体物种2]中的抗菌药物耐药性（AMR）对公共卫生构成了重大威胁。这些细菌常见于家畜、家禽、伴侣动物和野生动物中，是食源性疾病的主要病因，通常通过受污染的家禽传播。人类和兽医学中广泛使用抗生素产生了选择压力，通过点突变、水平基因转移和外排泵等机制推动了耐药性的产生。对氟喹诺酮类、大环内酯类和四环素类药物的耐药性使治疗变得复杂，并增加了严重感染的风险。耐药性[具体细菌名称]通过受污染的食物、水以及与动物的直接接触传播给人类，凸显了其人畜共患病的潜力。应对这一挑战需要有效的干预措施。诸如生物安全和基于免疫的方法等收获前策略可减少农场中的细菌载量，而收获后措施，包括屠体去污和冷冻，则可限制污染。诸如细菌素和天然抗菌剂等新兴方法提供了无化学物质的替代方案。整个食物链的综合多学科干预对于减轻AMR传播和提高食品安全至关重要。可持续农业实践、抗菌药物管理和创新解决方案对于遏制[具体细菌名称]耐药性和保护全球公共卫生至关重要。我们的综述研究了[具体细菌名称]中抗菌药物耐药性的动态，并提出了减轻与[具体细菌名称]相关的AMR的当前策略，为家禽业的抗菌控制提供了有价值的见解。
