Boda Zoltán, Schlammadinger Agota, László Pál, Lakos Gabriella, Kerényi Adrienn, Pfliegler György, Rázsó Katalin, Pósán Emóke
Debreceni Egyetem Orvos- és Egészségtudományi Centrum, II. Belgyógyászati Klinika, Haemostaseologiai Tanszék.
Orv Hetil. 2003 Jun 8;144(23):1131-4.
Antiphospholipid syndrome is an autoimmune disorder, defined as the association of antiphospholipid antibodies with manifestations of venous or arterial thrombosis or pregnancy loss. Primary antiphospholipid syndrome means that the patients have the same clinical symptoms and laboratory findings but they are not suffering from systemic lupus erythematosus or a closely related autoimmune diseases. Secondary antiphospholipid syndrome occurs in association with autoimmune or other diseases.
AIM, METHODS, RESULTS: 31 pregnancies of 10 women are detailed. 22 pregnancies were without thromboembolic prophylaxis and only 2 pregnancies were successful (9.1%). Out of the 9 pregnancies with high dose low-molecular-weight heparin and low dose aspirin thromboprophylaxis throughout pregnancy 8 were successful (88.8%). All the newborns were healthy. In spite of the long-term low-molecular-weight heparin therapy side effects (osteoporosis or heparin-induced thrombocytopenia) were not observed.
Considering these results high-dose low-molecular-weight heparin and low dose aspirin prophylaxis is recommended for pregnant women with antiphospholipid syndrome throughout pregnancy.
抗磷脂综合征是一种自身免疫性疾病，定义为抗磷脂抗体与静脉或动脉血栓形成或妊娠丢失的表现相关联。原发性抗磷脂综合征是指患者具有相同的临床症状和实验室检查结果，但不患有系统性红斑狼疮或密切相关的自身免疫性疾病。继发性抗磷脂综合征与自身免疫性疾病或其他疾病相关。
目的、方法、结果：详细介绍了10名女性的31次妊娠情况。22次妊娠未进行血栓栓塞预防，仅有2次妊娠成功（9.1%）。在整个孕期采用高剂量低分子量肝素和低剂量阿司匹林进行血栓预防的9次妊娠中，8次成功（88.8%）。所有新生儿均健康。尽管长期使用低分子量肝素治疗，但未观察到副作用（骨质疏松或肝素诱导的血小板减少症）。
考虑到这些结果，建议对患有抗磷脂综合征的孕妇在整个孕期采用高剂量低分子量肝素和低剂量阿司匹林进行预防。
